TY - JOUR
T1 - Plasma norepinephrine levels in infants and children with congestive heart failure
AU - Ross, Robert D.
AU - Daniels, Stephen R.
AU - Schwartz, David C.
AU - Hannon, David W.
AU - Shukla, Rakesh
AU - Kaplan, Samuel
N1 - Funding Information:
From the Division of Cardiology, Department of Pediatrics, Children’s Hospital Medical Center, and the Division of Biostatistics and Epidemiology, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio. This study was supported in part by the American Heart Association, Southwestern Ohio Chapter, Cincinnati, Ohio. Dr. Daniels is recipient of Public Health Service Clinical Investigator Award HL 01380 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland. Manuscript received September 12, 1986; revised manuscript received December 2,1986, accepted December 4, 1986.
PY - 1987/4/1
Y1 - 1987/4/1
N2 - To characterize the sympathetic nervous system response to congestive heart failure (CHF) in infants and children, plasma catecholamine levels were measured in 102 subjects undergoing routine cardiac catheterization (mean age 3.3 years, range 0.1 to 14.7), including 61 with left-to-right shunts. Plasma norepinephrine levels were significantly higher (p <0.0001) in children with CHF than in those without CHF. A highly significant association (p <0.0001) was found between the level of plasma norepinephrine and severity of CHF symptoms. This relation was found for CHF secondary to lesions producing a left-to-right shunt and CHF resulting from primary myocardial dysfunction. In congenital lesions with a left-to-right shunt, plasma norepinephrine levels correlated well with size of the shunt (Qp/Qs) (r = 0.75, p <0.001) and degree of pulmonary arterial hypertension (r = 0.70, p <0.001). Elevation of plasma norepinephrine concentrations in infants and children are seen with severe CHF regardless of its origin.
AB - To characterize the sympathetic nervous system response to congestive heart failure (CHF) in infants and children, plasma catecholamine levels were measured in 102 subjects undergoing routine cardiac catheterization (mean age 3.3 years, range 0.1 to 14.7), including 61 with left-to-right shunts. Plasma norepinephrine levels were significantly higher (p <0.0001) in children with CHF than in those without CHF. A highly significant association (p <0.0001) was found between the level of plasma norepinephrine and severity of CHF symptoms. This relation was found for CHF secondary to lesions producing a left-to-right shunt and CHF resulting from primary myocardial dysfunction. In congenital lesions with a left-to-right shunt, plasma norepinephrine levels correlated well with size of the shunt (Qp/Qs) (r = 0.75, p <0.001) and degree of pulmonary arterial hypertension (r = 0.70, p <0.001). Elevation of plasma norepinephrine concentrations in infants and children are seen with severe CHF regardless of its origin.
UR - http://www.scopus.com/inward/record.url?scp=0023179237&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(87)91118-0
DO - 10.1016/0002-9149(87)91118-0
M3 - Article
C2 - 3825955
AN - SCOPUS:0023179237
SN - 0002-9149
VL - 59
SP - 911
EP - 914
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 8
ER -