Platelet dysfunction during pediatric cardiac ECMO

Katherine Cashen, Amarilis Martin

Research output: Contribution to journalReview articlepeer-review


Pediatric extracorporeal membrane oxygenation (ECMO) is used for respiratory and cardiac failure refractory to conventional treatment. ECMO has been increasingly utilized for pediatric cardiac patients. Despite improved mortality, complications during and after ECMO are high and bleeding may be life threatening. Pediatric cardiac patients are at high risk for bleeding due to anticoagulation, surgery, and acquired platelet dysfunction. In this review, we focus on the many mechanisms contributing to platelet dysfunction, available monitoring of platelet function, what is known about platelet count and transfusion, treatment of bleeding, and future steps needed to improve our care for this patient population.

Original languageEnglish
Article number101187
JournalProgress in Pediatric Cardiology
StatePublished - Mar 2020


  • Cardiopulmonary bypass
  • Congenital heart disease
  • Extracorporeal membrane oxygenation
  • Platelet dysfunction


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