Pneumocystis pneumonia with hypogammaglobulinemia in a pediatric patient who underwent heart transplantation

Daiji Takajo; Swati Sehgal; Jennifer Blake; Sanjeev Aggarwal

doi:10.1111/tid.13571

Pneumocystis pneumonia with hypogammaglobulinemia in a pediatric patient who underwent heart transplantation

Daiji Takajo, Swati Sehgal, Jennifer Blake, Sanjeev Aggarwal

Research output: Contribution to journal › Article › peer-review

Abstract

A 23-month-old Caucasian female who had heart transplantation (HT) at 11 days of age was diagnosed with Pneumocystis pneumonia (PCP) in the setting of secondary hypogammaglobulinemia (HGG). She was diagnosed with HGG at 5 months of age and had been receiving monthly intravenous immunoglobulin infusion. This is the first case report describing the clinical course of PCP in a pediatric patient with HGG. She developed PCP 23 months after HT even when she was off steroids and was receiving timely IVIG. The case posed some clinical questions regarding PCP prophylaxis and HGG management.

Original language	English
Article number	e13571
Journal	Transplant Infectious Disease
Volume	23
Issue number	4
DOIs	https://doi.org/10.1111/tid.13571
State	Published - Aug 2021

Keywords

heart transplantation
hypogammaglobulinemia
immunoglobulin
pneumocystis pneumonia
prophylaxis

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10.1111/tid.13571

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title = "Pneumocystis pneumonia with hypogammaglobulinemia in a pediatric patient who underwent heart transplantation",

abstract = "A 23-month-old Caucasian female who had heart transplantation (HT) at 11 days of age was diagnosed with Pneumocystis pneumonia (PCP) in the setting of secondary hypogammaglobulinemia (HGG). She was diagnosed with HGG at 5 months of age and had been receiving monthly intravenous immunoglobulin infusion. This is the first case report describing the clinical course of PCP in a pediatric patient with HGG. She developed PCP 23 months after HT even when she was off steroids and was receiving timely IVIG. The case posed some clinical questions regarding PCP prophylaxis and HGG management.",

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AB - A 23-month-old Caucasian female who had heart transplantation (HT) at 11 days of age was diagnosed with Pneumocystis pneumonia (PCP) in the setting of secondary hypogammaglobulinemia (HGG). She was diagnosed with HGG at 5 months of age and had been receiving monthly intravenous immunoglobulin infusion. This is the first case report describing the clinical course of PCP in a pediatric patient with HGG. She developed PCP 23 months after HT even when she was off steroids and was receiving timely IVIG. The case posed some clinical questions regarding PCP prophylaxis and HGG management.

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KW - hypogammaglobulinemia

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KW - pneumocystis pneumonia

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Pneumocystis pneumonia with hypogammaglobulinemia in a pediatric patient who underwent heart transplantation

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