Polymorphisms in xenobiotic metabolism genes and autism

Fatema J. Serajee, Rafiqun Nabi, Hailang Zhong, A. H.M.Mahbubul Huq

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Autism is a neurodevelopmental syndrome defined by deficits in social reciprocity and communication and by unusual repetitive behaviors. Although there is an underlying genetic predisposition, the etiology of autism is currently unknown. A recent increase in prevalence suggests that genetically determined vulnerability to environmental exposure might contribute to the causation of autism. We performed family-based association studies of polymorphisms in metal-regulatory transcription factor 1(MTF1), a multispecific organic anion transporter (ABCC1), proton-coupled divalent metal ion transporters (SLC11A3 and SLC11A2), paraoxonase 1 (PON1), and glutathione S transferase (GSTP1) genes in 196 autistic disorder families. There was deviation from the expected pattern of transmission for polymorphisms in MTF1 (Single nucleotide polymorphism database reference identification number, dbSNP rs3790625, P = .02) and divalent metal ion transporter SLC11A3 (dbSNP rs2304704, P = .07) genes. Although these results might represent chance finding, further investigations of genetic variations of metal metabolism in autism are warranted.

Original languageEnglish
Pages (from-to)413-417
Number of pages5
JournalJournal of Child Neurology
Volume19
Issue number6
DOIs
StatePublished - Jun 2004

Fingerprint

Dive into the research topics of 'Polymorphisms in xenobiotic metabolism genes and autism'. Together they form a unique fingerprint.

Cite this