Polypharmacy and Food-Drug Interactions Among Older Persons: A Review

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37 Scopus citations


Polypharmacy is generally defined as the use of 5 or more prescription medications on a regular basis. The average number of prescribed and over-the-counter medications used by community-dwelling older adults per day in the United States is 6 medications, and the number used by institutionalized older persons is 9 medications. Almost all medications affect nutriture, either directly or indirectly, and nutriture affects drug disposition and effect. This review will highlight the issues surrounding polypharmacy, food-drug interactions, and the consequences of these interactions for the older adult.

Original languageEnglish
Pages (from-to)325-403
Number of pages79
JournalJournal of Nutrition in Gerontology and Geriatrics
Issue number4
StatePublished - Oct 2012


  • drug-nutrient interaction
  • older adult
  • polypharmacy


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