Abstract
In silico modeling is an increasingly powerful tool in probing processes driving
cancerous behavior and, in particular, tumor response to therapeutics. It has the
capability of integrating individually well-understood phenomena across a wide
range of scales, such as the vascular extravasation of oxygen and drug,
interstitial diffusion, and cells’ response to local concentrations in a spatially
multi-dimensional setting, thereby giving rise to behavior that is more than the
sum of its inputs. As such, the model can be used as an in silico laboratory,
investigating tumor therapeutic response under almost any conceivable set of
conditions. The results can suggest hypotheses to be corroborated by further in
vitro and in vivo experimentation, the convergence of results shedding light on
cancer phenomena and treatment.
Original language | English |
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Pages (from-to) | 485-510 |
Journal | Journal of Mathematical Biology/Springer |
Volume | 58 |
Issue number | 2-3 |
State | Published - Apr 2009 |