Primary hyperparathyroidism

Zeina Habib, Pauline Camacho

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Primary hyperparathyroidism (PHPT), a disease that classically manifests with hypercalcemia, bone disease and kidney stones, has over the past few decades changed into an asymptomatic, incidentally discovered condition. Although an exact etiology cannot always be identified, radiation exposure, genetic mutations and, most recently, prolonged vitamin D and/or calcium deficiency have been implicated. This article reviews epidemiology, pathophysiology, possible etiologies, and clinical presentation, as well as recommended approaches to diagnosis and management. The indications for surgery in patients with asymptomatic disease, long-term follow-up, and the treatment of co-existing vitamin D deficiency in patients with PHPT are also discussed. Finally, we briefly review the clinical manifestations and management of PHPT in pregnant women.

Original languageEnglish
Pages (from-to)375-387
Number of pages13
JournalExpert Review of Endocrinology and Metabolism
Issue number3
StatePublished - May 2010


  • Bisphosphonates
  • Bone loss
  • Calcimimetics
  • Hypercalciuria
  • Parathyroidectomy
  • Primary hyperparathyroidism
  • Vitamin D deficiency


Dive into the research topics of 'Primary hyperparathyroidism'. Together they form a unique fingerprint.

Cite this