TY - JOUR
T1 - Primary result of the efficacy and tolerance of gefitinib in advanced non-small cell lung cancer patients with brain metastasis
AU - Wang, Yan
AU - Wang, Ying
AU - Wang, Bin
AU - Wang, Ziping
AU - Zhang, Xiangru
AU - Chu, Datong
AU - Sun, Yan
PY - 2006/10/20
Y1 - 2006/10/20
N2 - Background and objective: Gefitinib, an orally active epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has shown targeted antitumor activity in patients with advanced non-small cell lung cancer (NSCLC). The aim of this study is to evaluate the efficacy and tolerance of gefitinib on brain metastasis in patients with NSCLC. Methods: The clinical characteristics, response to treatment and outcome of survival were retrospectively reviewed in eighteen NSCLC patients with brain metastasis. All these patients received gefitinib of 250 mg/d after brain metastasis was diagnosed. They would discontinued the targeted treatment because of disease progression or other reasons. Twelve of them received intracranial irradiation (group A), while the other six patients didn't (group B). Results: The overall response rate and disease controlled rate of gefitinib for brain lesions were 27.8% and 88.9% respectively (one complete remission, 4 partial remission, 11 stable disease, 2 progressive disease). No correlation among gender, smoking status, intracranial irradiation and the response of gefitinib was observed. There was no survival difference between the two groups (P = 0.192), with the median follow-up time of 6 months (range 1-24 months). Rash and diarrhea were the most common adverse events. Conclusion: Gefitinib is active in patients with brain metastasis from NSCLC. It is feasible to conduct randomized clinical trials to demonstrate the role of targeted treatment for NSCLC patients with metastatic brain lesions.
AB - Background and objective: Gefitinib, an orally active epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has shown targeted antitumor activity in patients with advanced non-small cell lung cancer (NSCLC). The aim of this study is to evaluate the efficacy and tolerance of gefitinib on brain metastasis in patients with NSCLC. Methods: The clinical characteristics, response to treatment and outcome of survival were retrospectively reviewed in eighteen NSCLC patients with brain metastasis. All these patients received gefitinib of 250 mg/d after brain metastasis was diagnosed. They would discontinued the targeted treatment because of disease progression or other reasons. Twelve of them received intracranial irradiation (group A), while the other six patients didn't (group B). Results: The overall response rate and disease controlled rate of gefitinib for brain lesions were 27.8% and 88.9% respectively (one complete remission, 4 partial remission, 11 stable disease, 2 progressive disease). No correlation among gender, smoking status, intracranial irradiation and the response of gefitinib was observed. There was no survival difference between the two groups (P = 0.192), with the median follow-up time of 6 months (range 1-24 months). Rash and diarrhea were the most common adverse events. Conclusion: Gefitinib is active in patients with brain metastasis from NSCLC. It is feasible to conduct randomized clinical trials to demonstrate the role of targeted treatment for NSCLC patients with metastatic brain lesions.
KW - Brain metastasis
KW - Gefitinib
KW - Non-small cell lung cancer
KW - Targeted therapy
UR - http://www.scopus.com/inward/record.url?scp=33750484335&partnerID=8YFLogxK
M3 - Review article
AN - SCOPUS:33750484335
SN - 1009-3419
VL - 9
SP - 447
EP - 451
JO - Chinese Journal of Lung Cancer
JF - Chinese Journal of Lung Cancer
IS - 5
ER -