Primary result of the efficacy and tolerance of gefitinib in advanced non-small cell lung cancer patients with brain metastasis

Yan Wang, Ying Wang, Bin Wang, Ziping Wang, Xiangru Zhang, Datong Chu, Yan Sun

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Background and objective: Gefitinib, an orally active epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has shown targeted antitumor activity in patients with advanced non-small cell lung cancer (NSCLC). The aim of this study is to evaluate the efficacy and tolerance of gefitinib on brain metastasis in patients with NSCLC. Methods: The clinical characteristics, response to treatment and outcome of survival were retrospectively reviewed in eighteen NSCLC patients with brain metastasis. All these patients received gefitinib of 250 mg/d after brain metastasis was diagnosed. They would discontinued the targeted treatment because of disease progression or other reasons. Twelve of them received intracranial irradiation (group A), while the other six patients didn't (group B). Results: The overall response rate and disease controlled rate of gefitinib for brain lesions were 27.8% and 88.9% respectively (one complete remission, 4 partial remission, 11 stable disease, 2 progressive disease). No correlation among gender, smoking status, intracranial irradiation and the response of gefitinib was observed. There was no survival difference between the two groups (P = 0.192), with the median follow-up time of 6 months (range 1-24 months). Rash and diarrhea were the most common adverse events. Conclusion: Gefitinib is active in patients with brain metastasis from NSCLC. It is feasible to conduct randomized clinical trials to demonstrate the role of targeted treatment for NSCLC patients with metastatic brain lesions.

Original languageEnglish
Pages (from-to)447-451
Number of pages5
JournalChinese Journal of Lung Cancer
Volume9
Issue number5
StatePublished - Oct 20 2006

Keywords

  • Brain metastasis
  • Gefitinib
  • Non-small cell lung cancer
  • Targeted therapy

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