TY - JOUR
T1 - Principal component analysis reveals gender-specific predictors of cardiometabolic risk in 6th graders
AU - Peterson, Mark D.
AU - Liu, Dongmei
AU - IglayReger, Heidi B.
AU - Saltarelli, William A.
AU - Visich, Paul S.
AU - Gordon, Paul M.
N1 - Funding Information:
Funding for this project was generously provided by Memorial Healthcare Foundation, as part of the Memorial FIT Kids program, Owosso, MI.
PY - 2012/11/28
Y1 - 2012/11/28
N2 - Background: The purpose of this study was to determine the sex-specific pattern of pediatric cardiometabolic risk with principal component analysis, using several biological, behavioral and parental variables in a large cohort (n = 2866) of 6th grade students.Methods: Cardiometabolic risk components included waist circumference, fasting glucose, blood pressure, plasma triglycerides levels and HDL-cholesterol. Principal components analysis was used to determine the pattern of risk clustering and to derive a continuous aggregate score (MetScore). Stratified risk components and MetScore were analyzed for association with age, body mass index (BMI), cardiorespiratory fitness (CRF), physical activity (PA), and parental factors.Results: In both boys and girls, BMI and CRF were associated with multiple risk components, and overall MetScore. Maternal smoking was associated with multiple risk components in girls and boys, as well as MetScore in boys, even after controlling for children's BMI. Paternal family history of early cardiovascular disease (CVD) and parental age were associated with increased blood pressure and MetScore for girls. Children's PA levels, maternal history of early CVD, and paternal BMI were also indicative for various risk components, but not MetScore.Conclusions: Several biological and behavioral factors were independently associated with children's cardiometabolic disease risk, and thus represent a unique gender-specific risk profile. These data serve to bolster the independent contribution of CRF, PA, and family-oriented healthy lifestyles for improving children's health.
AB - Background: The purpose of this study was to determine the sex-specific pattern of pediatric cardiometabolic risk with principal component analysis, using several biological, behavioral and parental variables in a large cohort (n = 2866) of 6th grade students.Methods: Cardiometabolic risk components included waist circumference, fasting glucose, blood pressure, plasma triglycerides levels and HDL-cholesterol. Principal components analysis was used to determine the pattern of risk clustering and to derive a continuous aggregate score (MetScore). Stratified risk components and MetScore were analyzed for association with age, body mass index (BMI), cardiorespiratory fitness (CRF), physical activity (PA), and parental factors.Results: In both boys and girls, BMI and CRF were associated with multiple risk components, and overall MetScore. Maternal smoking was associated with multiple risk components in girls and boys, as well as MetScore in boys, even after controlling for children's BMI. Paternal family history of early cardiovascular disease (CVD) and parental age were associated with increased blood pressure and MetScore for girls. Children's PA levels, maternal history of early CVD, and paternal BMI were also indicative for various risk components, but not MetScore.Conclusions: Several biological and behavioral factors were independently associated with children's cardiometabolic disease risk, and thus represent a unique gender-specific risk profile. These data serve to bolster the independent contribution of CRF, PA, and family-oriented healthy lifestyles for improving children's health.
KW - Cardiorespiratory fitness
KW - Obesity
KW - Pediatrics
KW - Principal component analysis
UR - http://www.scopus.com/inward/record.url?scp=84870064646&partnerID=8YFLogxK
U2 - 10.1186/1475-2840-11-146
DO - 10.1186/1475-2840-11-146
M3 - Article
C2 - 23190687
AN - SCOPUS:84870064646
SN - 1475-2840
VL - 11
JO - Cardiovascular Diabetology
JF - Cardiovascular Diabetology
M1 - 146
ER -