Pro-opiomelanocortin peptides and the adrenal gland

Jason Karpac, Andras Kern, Ute Hochgeschwender

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

The adrenal gland regulates a number of essential biological functions through production of steroids and catecholamines. Pro-opiomelanocortin (POMC)-derived peptides have been implicated in all aspects of generating, maintaining, and functioning of the adrenal glands. An appreciation for the roles of POMC-derived peptides with respect to the adrenal has been gained from experiments in vitro, and in vivo in different animal models which surgically, pharmacologically, or genetically decrease or increase the amount of POMC peptides available. We recently produced a mouse model with a deletion of the entire coding region of the POMC gene, thus lacking all POMC-derived peptides, from all sources, and at all times. Here we will summarize and discuss the results of traditional in vivo studies on the role of POMC peptides in adrenal development, maintenance, and function in the context of findings in a mouse model genetically lacking all POMC-derived peptides.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalMolecular and Cellular Endocrinology
Volume265-266
Issue numberSUPPL.
DOIs
StatePublished - Feb 2007

Keywords

  • Adrenal
  • Genetic model
  • Mouse
  • POMC
  • Peptides

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