Progressively worsening hypertrophic cardiomyopathy in a child with newly diagnosed Costello syndrome while receiving growth hormone therapy

Daisuke Kobayashi, Amanda L. Cook, Derek A. Williams

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We describe a 6-year-old boy with newly diagnosed Costello syndrome after the diagnosis of severe hypertrophic cardiomyopathy. His neonatal asymmetric septal cardiomyopathy resolved by 9 months of age but reappeared at 6 years of age. This report highlights two important concepts: the association of genetic syndromes with hypertrophic cardiomyopathy and the possibility of worsening severity of hypertrophic cardiomyopathy linked to growth hormone therapy.

Original languageEnglish
Pages (from-to)459-461
Number of pages3
JournalCardiology in the Young
Volume20
Issue number4
DOIs
StatePublished - Aug 2010
Externally publishedYes

Keywords

  • Genetic syndromes
  • HRAS gene mutation
  • neonatal cardiomyopathy

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