@inbook{0f5d7e29cd4c4af6924f77ec784082a8,
title = "Proteomics and systems biology in optic nerve regeneration",
abstract = "We present an overview of current state of proteomic approaches as applied to optic nerve regeneration in the historical context of nerve regeneration particularly central nervous system neuronal regeneration. We present outlook pertaining to the optic nerve regeneration proteomics that the latter can extrapolate information from multi-systems level investigations. We present an account of the current need of systems level standardization for comparison of proteome from various models and across different pharmacological or biophysical treatments that promote adult neuron regeneration. We briefly overview the need for deriving knowledge from proteomics and integrating with other omics to obtain greater biological insight into process of adult neuron regeneration in the optic nerve and its potential applicability to other central nervous system neuron regeneration.",
keywords = "Axon regeneration, Central nervous system, Lipidomics, Mass spectrometry, Metabolomics, Optic nerve regeneration, Proteomics, Vision",
author = "Meehan, {Sean D.} and Leila Abdelrahman and Jennifer Arcuri and Park, {Kevin K.} and Mohammad Samarah and Bhattacharya, {Sanjoy K.}",
note = "Funding Information: This work was supported by NIH grants: U01EY027257, P30EY014801, US Department of Defense grant W81XWH1910845 and an unrestricted grant from Research to Prevent Blindness. We thank all authors in this field whose work was cited and those we were unable to acknowledge in this review. We have refrained from compartment level proteomics in this area due to its very emergent and incomplete nature. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = jan,
doi = "10.1016/bs.apcsb.2021.03.002",
language = "English",
isbn = "9780323853194",
series = "Advances in Protein Chemistry and Structural Biology",
publisher = "Academic Press Inc.",
pages = "249--270",
editor = "Rossen Donev and Tatyana Karabencheva-Christova",
booktitle = "Proteomics and Systems Biology",
}