Pulmonary embolism-experience at a single children's hospital

Madhvi Rajpurkar, Indira Warrier, Meera Chitlur, Cynthia Sabo, Mary Jane Frey, Wendy Hollon, Jeanne Lusher

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Introduction: Pulmonary embolism in children is a rare, potentially life threatening condition. The clinical characteristics of pediatric pulmonary embolism have not been well studied and the exact incidence in children is not known. We report a case series of fourteen patients with pulmonary embolism and describe their clinical characteristics. Materials and methods: Inpatient and outpatient clinic charts of patients with proven pulmonary embolism (PE) followed at the Hemostasis and Thrombosis Center at Children's Hospital of Michigan were reviewed for relevant clinical and laboratory information. Results: All patients with PE were symptomatic but accurate diagnosis of PE was often delayed in the outpatient setting. Screening testing with D-dimer was normal in 40% of patients. Acquired risk factors and lower extremity clots were more common in patients analyzed. Treatment regimens differed but most patients had resolution of pulmonary emboli on follow-up. Conclusions: A high index of suspicion is needed for the diagnosis of pediatric PE. D-Dimer may be normal in some children with PE. Pediatric multicenter trials are needed to evaluate clinical characteristics, risk factors, long-term outcome and effects of PE on pulmonary and cardiac function.

Original languageEnglish
Pages (from-to)699-703
Number of pages5
JournalThrombosis Research
Issue number6
StatePublished - 2007
Externally publishedYes


  • Anticoagulation therapy
  • Pediatric
  • Pulmonary embolism


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