Quality of life in adolescents and adults with CHARGE syndrome

Nancy Hartshorne, Alexandra Hudson, Jillian MacCuspie, Benjamin Kennert, Tasha Nacarato, Timothy Hartshorne, Kim Blake

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Health-related Quality of Life and the Impact of Childhood Neurologic Disability Scale were collected for 53 patients with CHARGE syndrome aged 13–39 years with a mean academic level of 4th grade. The most prevalent new and ongoing issues included bone health issues, sleep apnea, retinal detachment, anxiety, and aggression. Sleep issues were significantly correlated with anxiety, self-abuse, conduct problems, and autistic-like behaviors. Problems with overall health, behavior, and balance most affected the number of social activities in the individual's life. Sensory impairment most affected relationships with friends. Two contrasting case studies are presented and demonstrate that the quality of life exists on a broad spectrum in CHARGE syndrome, just as its physical features range from mild to very severe. A multitude of factors, including those beyond the physical manifestations, such as anxiety and sleep problems, influence quality of life and are important areas for intervention.

Original languageEnglish
Pages (from-to)2012-2021
Number of pages10
JournalAmerican Journal of Medical Genetics, Part A
Issue number8
StatePublished - Aug 1 2016


  • CHARGE syndrome
  • adolescent
  • adult
  • development
  • quality of life


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