Quantitative measurement of cell adhesion using centrifugal force.

D. R. McClay, P. L. Hertzler

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


In order to study the biophysical forces involved in cell-substrate (or cell-cell) adhesion, it is necessary to measure the strength of adhesion. Two questions can be addressed using the centrifugal cell adhesion assay provided in this unit: what is the ligand-receptor affinity for cells adhering at 4 degrees C and what is the strength of the ATP-dependent processes that strengthen adhesion at 37 degrees C. In both cases, the strength of adhesion is measured as the resistance to disruption in the presence of a measured centrifugal force.

Original languageEnglish
Pages (from-to)Unit 9.2
JournalCurrent protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.]
VolumeChapter 9
StatePublished - May 2001


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