Recurrent Atypical Hemolytic Uremic Syndrome in Children with Acute Lymphoblastic Leukemia Undergoing Maintenance Chemotherapy

Geoffrey Cheng; Bulent Ozgonenel; Kanta Bhambhani; Gaurav Kapur; Richard J. Smith; Süreyya Savaşan

doi:10.1097/MPH.0000000000000987

Recurrent Atypical Hemolytic Uremic Syndrome in Children with Acute Lymphoblastic Leukemia Undergoing Maintenance Chemotherapy

Geoffrey Cheng, Bulent Ozgonenel, Kanta Bhambhani, Gaurav Kapur, Richard J. Smith, Süreyya Savaşan

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Chemotherapy-associated myelosuppression and renal dysfunction is not uncommon during childhood acute lymphoblastic leukemia (ALL) therapy. Here we report 2 cases of atypical hemolytic uremic syndrome (aHUS) presenting with pancytopenia and renal dysfunction that developed during maintenance chemotherapy characterized by hypocomplementemia. Both cases experienced recurrence after resolution of the initial aHUS episode upon resumption of chemotherapy, raising a possible contributory role for chemotherapy in the disease pathogenesis.

Original language	English
Pages (from-to)	560-562
Number of pages	3
Journal	Journal of Pediatric Hematology/Oncology
Volume	40
Issue number	7
DOIs	https://doi.org/10.1097/MPH.0000000000000987
State	Published - Oct 1 2018

Keywords

acute lymphoblastic leukemia
atypical hemolytic uremic syndrome
chemotherapy
complement

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10.1097/MPH.0000000000000987

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title = "Recurrent Atypical Hemolytic Uremic Syndrome in Children with Acute Lymphoblastic Leukemia Undergoing Maintenance Chemotherapy",

abstract = "Chemotherapy-associated myelosuppression and renal dysfunction is not uncommon during childhood acute lymphoblastic leukemia (ALL) therapy. Here we report 2 cases of atypical hemolytic uremic syndrome (aHUS) presenting with pancytopenia and renal dysfunction that developed during maintenance chemotherapy characterized by hypocomplementemia. Both cases experienced recurrence after resolution of the initial aHUS episode upon resumption of chemotherapy, raising a possible contributory role for chemotherapy in the disease pathogenesis.",

keywords = "acute lymphoblastic leukemia, atypical hemolytic uremic syndrome, chemotherapy, complement",

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T1 - Recurrent Atypical Hemolytic Uremic Syndrome in Children with Acute Lymphoblastic Leukemia Undergoing Maintenance Chemotherapy

AU - Cheng, Geoffrey

AU - Ozgonenel, Bulent

AU - Bhambhani, Kanta

AU - Kapur, Gaurav

AU - Smith, Richard J.

AU - Savaşan, Süreyya

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Chemotherapy-associated myelosuppression and renal dysfunction is not uncommon during childhood acute lymphoblastic leukemia (ALL) therapy. Here we report 2 cases of atypical hemolytic uremic syndrome (aHUS) presenting with pancytopenia and renal dysfunction that developed during maintenance chemotherapy characterized by hypocomplementemia. Both cases experienced recurrence after resolution of the initial aHUS episode upon resumption of chemotherapy, raising a possible contributory role for chemotherapy in the disease pathogenesis.

AB - Chemotherapy-associated myelosuppression and renal dysfunction is not uncommon during childhood acute lymphoblastic leukemia (ALL) therapy. Here we report 2 cases of atypical hemolytic uremic syndrome (aHUS) presenting with pancytopenia and renal dysfunction that developed during maintenance chemotherapy characterized by hypocomplementemia. Both cases experienced recurrence after resolution of the initial aHUS episode upon resumption of chemotherapy, raising a possible contributory role for chemotherapy in the disease pathogenesis.

KW - acute lymphoblastic leukemia

KW - atypical hemolytic uremic syndrome

KW - chemotherapy

KW - complement

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JF - Journal of Pediatric Hematology/Oncology

SN - 1077-4114

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ER -

Recurrent Atypical Hemolytic Uremic Syndrome in Children with Acute Lymphoblastic Leukemia Undergoing Maintenance Chemotherapy

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