Recurrent Atypical Hemolytic Uremic Syndrome in Children with Acute Lymphoblastic Leukemia Undergoing Maintenance Chemotherapy

Geoffrey Cheng, Bulent Ozgonenel, Kanta Bhambhani, Gaurav Kapur, Richard J. Smith, Süreyya Savaşan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Chemotherapy-associated myelosuppression and renal dysfunction is not uncommon during childhood acute lymphoblastic leukemia (ALL) therapy. Here we report 2 cases of atypical hemolytic uremic syndrome (aHUS) presenting with pancytopenia and renal dysfunction that developed during maintenance chemotherapy characterized by hypocomplementemia. Both cases experienced recurrence after resolution of the initial aHUS episode upon resumption of chemotherapy, raising a possible contributory role for chemotherapy in the disease pathogenesis. ©

Original languageEnglish
Pages (from-to)560-562
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume40
Issue number7
DOIs
StatePublished - Oct 1 2018

Keywords

  • acute lymphoblastic leukemia
  • atypical hemolytic uremic syndrome
  • chemotherapy
  • complement

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