Reduction of anterograde degeneration in brain damaged rats by GM1-gangliosides

Bernhard A. Sabel, Robert DelMastro, Gary L. Dunbar, Donald G. Stein

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

After receiving a nigrostriatal hemitransection in the left hemisphere and an electrolytic caudate nucleus (CN) lesion in the right hemisphere, rats were given intraperitoneal injections of saline or GM1-gangliosides. Significantly smaller areas of terminal degeneration were seen in the substantia nigra pars reticulata (SNr) ipsilateral to the caudate lesion of animals treated with GM1. No statistical differences were seen in the number of degenerating terminals in the CN and SNr on the side with the hemitransection. Exogenous GM1 may thus be effective in preventing anterograde degeneration following brain injury.

Original languageEnglish
Pages (from-to)360-366
Number of pages7
JournalNeuroscience Letters
Volume77
Issue number3
DOIs
StatePublished - Jun 26 1987

Keywords

  • Anterograde degeneration
  • Brain damage
  • Ganglioside
  • Nigrostriatal system

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