Regional Distribution of Glutathione Peroxidase in the Adult Rat Brain

Timothy S. Brannan, Howard S. Maker, Cipora Weiss, Gerald Cohen

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Glutathione peroxidase activity was measured in 10 areas of perfused adult rat brain with the use of a fluorometric assay coupled to NADPH oxidation. The caudate‐putamen and the substantia nigra had the highest activities. Cortical areas and several nuclear areas had somewhat lower activity. Activity was lowest in a white matter structure (corpus callosum). High activity of glutathione peroxidase may be related to the need to reduce hydrogen peroxide arising in the course of monoamine metabolism.

Original languageEnglish
Pages (from-to)1013-1014
Number of pages2
JournalJournal of Neurochemistry
Volume35
Issue number4
DOIs
StatePublished - Oct 1980

Keywords

  • Glutathione peroxidase—Hydrogen peroxide—Regional distribution. Brannan T. S. et al. Regional distribution of glutathione peroxidase in the adult rat brain. J. Neurochem.35, 1013–1014 (1980)

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