Regional distribution of glutathione reductase in the adult rat brain

Timothy S. Brannan, Howard S. Maker, Ingrid Raes, Cipora Weiss

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Glutathione reductase was measured in 10 selected areas of the adult rat brain. Activities varied over a 2.5-fold range. The caudate-putamen and cortical areas contained the highest activities. Several gray matter structures contained intermediate activities. The substantia nigra and the corpus callosum, a white matter structure, contained the lowest activities. The caudate-putamen, a catecholamine rich area, may produce H2O2 via MAO and would require glutathione reductase to recycle glutathione oxidized by glutathione peroxidase. However, the distribution of glutathione reductase activity also suggests a role in reducing oxidants formed during tissue respiration.

Original languageEnglish
Pages (from-to)474-477
Number of pages4
JournalBrain Research
Issue number2
StatePublished - Nov 3 1980


  • glutathione
  • glutathione reductase
  • peroxide metabolism


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