Renal medullary carcinoma and sickle cell trait: A systematic review

Ofelia Alvarez; Maria M. Rodriguez; Lanetta Jordan; Sharada Sarnaik

doi:10.1002/pbc.25592

Renal medullary carcinoma and sickle cell trait: A systematic review

Ofelia Alvarez, Maria M. Rodriguez, Lanetta Jordan, Sharada Sarnaik

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

Sickle cell trait (SCT) carries a small risk of renal medullary carcinoma (RMC). We conducted a systematic literature review and reported new four RMC cases (total N=217). Eighty eight percent had SCT and 8% had sickle cell disease; 50% were children. Males had 2.4× risk than females. Isolated hematuria or in combination with abdominal or flank pain was the presenting sign in 66% cases. Tumor-related mortality was 95%. Four non-metastatic patients were long-term disease-free survivors. Although risk appears to be very low, individuals with SCT should be informed about the low risk of RMC with the hope of early diagnosis. Hematuria should prompt immediate investigation.

Original language	English
Pages (from-to)	1694-1699
Number of pages	6
Journal	Pediatric Blood and Cancer
Volume	62
Issue number	10
DOIs	https://doi.org/10.1002/pbc.25592
State	Published - Oct 1 2015
Externally published	Yes

Keywords

Cancer
Rare tumors
Renal
Sickle cell disease
Sickle cell trait
Tumors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/pbc.25592

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title = "Renal medullary carcinoma and sickle cell trait: A systematic review",

abstract = "Sickle cell trait (SCT) carries a small risk of renal medullary carcinoma (RMC). We conducted a systematic literature review and reported new four RMC cases (total N=217). Eighty eight percent had SCT and 8% had sickle cell disease; 50% were children. Males had 2.4× risk than females. Isolated hematuria or in combination with abdominal or flank pain was the presenting sign in 66% cases. Tumor-related mortality was 95%. Four non-metastatic patients were long-term disease-free survivors. Although risk appears to be very low, individuals with SCT should be informed about the low risk of RMC with the hope of early diagnosis. Hematuria should prompt immediate investigation.",

keywords = "Cancer, Rare tumors, Renal, Sickle cell disease, Sickle cell trait, Tumors",

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T1 - Renal medullary carcinoma and sickle cell trait

T2 - A systematic review

AU - Alvarez, Ofelia

AU - Rodriguez, Maria M.

AU - Jordan, Lanetta

AU - Sarnaik, Sharada

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Sickle cell trait (SCT) carries a small risk of renal medullary carcinoma (RMC). We conducted a systematic literature review and reported new four RMC cases (total N=217). Eighty eight percent had SCT and 8% had sickle cell disease; 50% were children. Males had 2.4× risk than females. Isolated hematuria or in combination with abdominal or flank pain was the presenting sign in 66% cases. Tumor-related mortality was 95%. Four non-metastatic patients were long-term disease-free survivors. Although risk appears to be very low, individuals with SCT should be informed about the low risk of RMC with the hope of early diagnosis. Hematuria should prompt immediate investigation.

AB - Sickle cell trait (SCT) carries a small risk of renal medullary carcinoma (RMC). We conducted a systematic literature review and reported new four RMC cases (total N=217). Eighty eight percent had SCT and 8% had sickle cell disease; 50% were children. Males had 2.4× risk than females. Isolated hematuria or in combination with abdominal or flank pain was the presenting sign in 66% cases. Tumor-related mortality was 95%. Four non-metastatic patients were long-term disease-free survivors. Although risk appears to be very low, individuals with SCT should be informed about the low risk of RMC with the hope of early diagnosis. Hematuria should prompt immediate investigation.

KW - Cancer

KW - Rare tumors

KW - Renal

KW - Sickle cell disease

KW - Sickle cell trait

KW - Tumors

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SN - 1545-5009

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EP - 1699

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 10

ER -

Renal medullary carcinoma and sickle cell trait: A systematic review

Abstract

Keywords

UN SDGs

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