Renal medullary carcinoma and sickle cell trait: A systematic review

Ofelia Alvarez, Maria M. Rodriguez, Lanetta Jordan, Sharada Sarnaik

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


Sickle cell trait (SCT) carries a small risk of renal medullary carcinoma (RMC). We conducted a systematic literature review and reported new four RMC cases (total N=217). Eighty eight percent had SCT and 8% had sickle cell disease; 50% were children. Males had 2.4× risk than females. Isolated hematuria or in combination with abdominal or flank pain was the presenting sign in 66% cases. Tumor-related mortality was 95%. Four non-metastatic patients were long-term disease-free survivors. Although risk appears to be very low, individuals with SCT should be informed about the low risk of RMC with the hope of early diagnosis. Hematuria should prompt immediate investigation.

Original languageEnglish
Pages (from-to)1694-1699
Number of pages6
JournalPediatric Blood and Cancer
Issue number10
StatePublished - Oct 1 2015
Externally publishedYes


  • Cancer
  • Rare tumors
  • Renal
  • Sickle cell disease
  • Sickle cell trait
  • Tumors


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