Renal papillary necrosis induced by naproxen

Larisa Kovacevic, Jay Bernstein, Rudolph P. Valentini, Abubakr Imam, Neena Gupta, Tej K. Mattoo

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


A 17-year-old healthy girl was admitted to our hospital with diffuse abdominal pain and decreased oral intake of about 11 days duration. About a week prior to admission, she had taken naproxen, 250 mg four times a day for 4 days. Physical examination was normal except for diffuse abdominal tenderness on deep palpation. Investigations revealed high serum BUN (42 mg/dl) and creatinine (4.0 mg/dl). Serum electrolytes and complement (C3, C4) levels and urinalysis were normal. Anti-nuclear-antibody and anti-dsDNA were negative. Kidney biopsy revealed renal papillary necrosis, acute tubular necrosis, and focal interstitial nephritis. A diagnosis of nonoliguric acute renal failure due to naproxen nephrotoxicity was made. She received intravenous hydration, and oral steroids, which was gradually discontinued in 3 months. A follow-up at 4 months revealed normal renal function with a serum creatinine of 1.1 mg/dl, BUN 7 mg/dl, and normal urinalysis. The report highlights a need for caution while using naproxen or any other nonsteroidal anti-inflammatory drugs, even for a short duration.

Original languageEnglish
Pages (from-to)826-829
Number of pages4
JournalPediatric Nephrology
Issue number8
StatePublished - Aug 1 2003


  • Acute renal failure
  • Children
  • Naproxen
  • Nonsteroidal anti-inflammatory drugs
  • Renal papillary necrosis


Dive into the research topics of 'Renal papillary necrosis induced by naproxen'. Together they form a unique fingerprint.

Cite this