TY - JOUR
T1 - Repeat charcoal hemoperfusion treatments in life threatening carbamazepine overdose
AU - Deshpande, Girish
AU - Meert, Kathleen L.
AU - Valentini, Rudolph P.
PY - 1999/11
Y1 - 1999/11
N2 - A 16-month-old female experienced a massive carbamazepine ingestion resulting in a peak carbamazepine concentration of 55 μg/ml. Clinical manifestations included generalized seizures, coma, shock, and gastrointestinal hypomotility, Gut decontamination was attempted using multiple-dose activated charcoal and cathartics. Because of the severity of illness, charcoal hemoperfusion was initiated. The patient underwent three sessions of charcoal hemoperfusion, each utilizing a fresh cartridge, with one session immediately following the other. Serum carbamazepine and carbamazepine-10,11-epoxide concentrations decreased from 54 μg/ml to 23 μg/ml, and 30 μg/ml to 17 μg/ml, respectively, during charcoal hemoperfusion. There were no complications. The patient recovered completely and was discharged on the 4th hospital day. Charcoal hemoperfusion should be considered for life-threatening carbamazepine intoxication, especially when drug-induced gastrointestinal hypomotility prevents elimination via the gut.
AB - A 16-month-old female experienced a massive carbamazepine ingestion resulting in a peak carbamazepine concentration of 55 μg/ml. Clinical manifestations included generalized seizures, coma, shock, and gastrointestinal hypomotility, Gut decontamination was attempted using multiple-dose activated charcoal and cathartics. Because of the severity of illness, charcoal hemoperfusion was initiated. The patient underwent three sessions of charcoal hemoperfusion, each utilizing a fresh cartridge, with one session immediately following the other. Serum carbamazepine and carbamazepine-10,11-epoxide concentrations decreased from 54 μg/ml to 23 μg/ml, and 30 μg/ml to 17 μg/ml, respectively, during charcoal hemoperfusion. There were no complications. The patient recovered completely and was discharged on the 4th hospital day. Charcoal hemoperfusion should be considered for life-threatening carbamazepine intoxication, especially when drug-induced gastrointestinal hypomotility prevents elimination via the gut.
KW - Carbamazepine
KW - Charcoal hemoperfusion
KW - Ileus
KW - Poisoning
UR - http://www.scopus.com/inward/record.url?scp=0032785595&partnerID=8YFLogxK
U2 - 10.1007/s004670050698
DO - 10.1007/s004670050698
M3 - Article
C2 - 10603119
AN - SCOPUS:0032785595
VL - 13
SP - 775
EP - 777
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 9
ER -