Reversible Cerebral Vasoconstriction Syndrome and Sickle Cell Disease: A Case Report

Katherine Regling, Daniel Pomerantz, Sandra Narayanan, Deniz Altinok, Lalitha Sivaswamy, Neena I. Marupudi, Michael U. Callaghan, Alissa Martin

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Reversible cerebral vasoconstriction syndrome (RCVS), is rare in the pediatric population and is characterized by severe headaches and other neurologic symptoms. We present a case of RCVS occurring concomitantly with posterior reversible encephalopathy syndrome in an 8-year-old African American child with sickle cell disease (HbSS). Imaging studies including computed tomography, magnetic resonance imaging and cerebral angiography of the brain showed acute hemorrhagic stroke and a beaded appearance of peripheral cerebral vessels. In this report, we focus on the typical features of RCVS and discuss the underlying risk factors that may increase the risk in patients with HbSS disease.

Original languageEnglish
Pages (from-to)E95-E98
JournalJournal of Pediatric Hematology/Oncology
Issue number1
StatePublished - Jan 2021


  • pediatrics
  • posterior reversible encephalopathy syndrome
  • reversible cerebral vasoconstriction syndrome
  • sickle cell disease
  • stroke


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