TY - JOUR
T1 - Role of epigenetics in stem cell proliferation and differentiation
T2 - Implications for treating neurodegenerative diseases
AU - Srinageshwar, Bhairavi
AU - Maiti, Panchanan
AU - Dunbar, Gary L.
AU - Rossignol, Julien
N1 - Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2016/2/2
Y1 - 2016/2/2
N2 - The main objectives of this review are to survey the current literature on the role of epigenetics in determining the fate of stem cells and to assess how this information can be used to enhance the treatment strategies for some neurodegenerative disorders, like Huntington’s disease, Parkinson’s disease and Alzheimer’s disease. Some of these epigenetic mechanisms include DNA methylation and histone modifications, which have a direct impact on the way that genes are expressed in stem cells and how they drive these cells into a mature lineage. Understanding how the stem cells are behaving and giving rise to mature cells can be used to inform researchers on effective ways to design stem cell-based treatments. In this review article, the way in which the basic understanding of how manipulating this process can be utilized to treat certain neurological diseases will be presented. Different genetic factors and their epigenetic changes during reprogramming of stem cells into induced pluripotent stem cells (iPSCs) have significant potential for enhancing the efficacy of cell replacement therapies.
AB - The main objectives of this review are to survey the current literature on the role of epigenetics in determining the fate of stem cells and to assess how this information can be used to enhance the treatment strategies for some neurodegenerative disorders, like Huntington’s disease, Parkinson’s disease and Alzheimer’s disease. Some of these epigenetic mechanisms include DNA methylation and histone modifications, which have a direct impact on the way that genes are expressed in stem cells and how they drive these cells into a mature lineage. Understanding how the stem cells are behaving and giving rise to mature cells can be used to inform researchers on effective ways to design stem cell-based treatments. In this review article, the way in which the basic understanding of how manipulating this process can be utilized to treat certain neurological diseases will be presented. Different genetic factors and their epigenetic changes during reprogramming of stem cells into induced pluripotent stem cells (iPSCs) have significant potential for enhancing the efficacy of cell replacement therapies.
KW - Alzheimer’s disease
KW - Epigenetics
KW - Histone modifications
KW - Huntington’s disease
KW - Induced pluripotent stem cells (iPSCs)
KW - Mesenchymal stem cells (MSCs)
KW - Neural stem cells (NSCs)
KW - Neurodegenerative diseases
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=84956917735&partnerID=8YFLogxK
U2 - 10.3390/ijms17020199
DO - 10.3390/ijms17020199
M3 - Review article
C2 - 26848657
AN - SCOPUS:84956917735
VL - 17
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 2
M1 - 199
ER -