TY - JOUR
T1 - Role of protein kinase C as a cellular mediator of ischemic preconditioning
T2 - A critical review
AU - Simkhovich, Boris Z.
AU - Przyklenk, Karin
AU - Kloner, Robert A.
PY - 1998/10/1
Y1 - 1998/10/1
N2 - Protein kinase C (PKC) has been proposed as a primary cellular mediator of ischemic preconditioning. However, the role of PKC in eliciting cardioprotection remains controversial. In this review, we summarize the evidence for and against the 'PKC hypothesis' of preconditioning, discuss the important technical limitations currently hampering PKC research, and suggest new approaches (i.e. PKC isoform-specific biochemical assays combined with immunoblotting techniques) that might aid in the definite resolution of this issue.
AB - Protein kinase C (PKC) has been proposed as a primary cellular mediator of ischemic preconditioning. However, the role of PKC in eliciting cardioprotection remains controversial. In this review, we summarize the evidence for and against the 'PKC hypothesis' of preconditioning, discuss the important technical limitations currently hampering PKC research, and suggest new approaches (i.e. PKC isoform-specific biochemical assays combined with immunoblotting techniques) that might aid in the definite resolution of this issue.
KW - Ischemic preconditioning
KW - Protein kinase C
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=0032190473&partnerID=8YFLogxK
U2 - 10.1016/S0008-6363(98)00142-4
DO - 10.1016/S0008-6363(98)00142-4
M3 - Review article
C2 - 9876313
AN - SCOPUS:0032190473
SN - 0008-6363
VL - 40
SP - 9
EP - 22
JO - Cardiovascular Research
JF - Cardiovascular Research
IS - 1
ER -