Role of protein kinase C as a cellular mediator of ischemic preconditioning: A critical review

Boris Z. Simkhovich, Karin Przyklenk, Robert A. Kloner

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations

Abstract

Protein kinase C (PKC) has been proposed as a primary cellular mediator of ischemic preconditioning. However, the role of PKC in eliciting cardioprotection remains controversial. In this review, we summarize the evidence for and against the 'PKC hypothesis' of preconditioning, discuss the important technical limitations currently hampering PKC research, and suggest new approaches (i.e. PKC isoform-specific biochemical assays combined with immunoblotting techniques) that might aid in the definite resolution of this issue.

Original languageEnglish
Pages (from-to)9-22
Number of pages14
JournalCardiovascular Research
Volume40
Issue number1
DOIs
StatePublished - Oct 1 1998

Keywords

  • Ischemic preconditioning
  • Protein kinase C
  • Signal transduction

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