Role of the vector in arbovirus transmission

Michael J. Conway, Tonya M. Colpitts, Erol Fikrig

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Many arboviral diseases are uncontrolled, and the viruses that cause them are globally emerging or reemerging pathogens that produce significant disease throughout the world. The increased spread and prevalence of disease are occurring during a period of substantial scientific growth in the vector-borne disease research community. This growth has been supported by advances in genomics and proteomics, and by the ability to genetically alter disease vectors. For the first time, researchers are elucidating the molecular details of vector host-seeking behavior, the susceptibility of disease vectors to arboviruses, the immunological control of infection in disease vectors, and the determinants that facilitate transmission of arboviruses from a vector to a host. These discoveries are facilitating the development of novel strategies to combat arboviral disease, including the release of transgenic mosquitoes harboring dominant lethal genes, the introduction of arbovirus-blocking microbes into mosquito populations, and the development of acquisition- and transmission-blocking therapeutics. Understanding the role of the vector in arbovirus transmission has provided critical practical and theoretical tools to control arboviral disease.

Original languageEnglish
Pages (from-to)71-88
Number of pages18
JournalAnnual Review of Virology
Volume1
Issue number1
DOIs
StatePublished - Sep 29 2014

Keywords

  • Host
  • Immune response
  • Mosquito
  • Saliva protein

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