Self-immolative phthalate esters sensitive to hydrogen peroxide and light

Kaitlyn M. Mahoney, Pratik P. Goswami, Aleem Syed, Patrick Kolker, Brian Shannan, Emily A. Smith, Arthur H. Winter

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Self-immolative aryl phthalate esters were conjugated with cleavable masking groups sensitive to light and hydrogen peroxide. The phthalate linker releases the fluorescent dye 7-hydroxycoumarin upon exposure to light or H2O2, respectively, leading to an increase in fluorescence. The light-sensitive aryl phthalate ester is demonstrated as a pro-fluorophore in cultured S2 cells.

Original languageEnglish
Pages (from-to)11740-11743
Number of pages4
JournalJournal of Organic Chemistry
Issue number23
StatePublished - Dec 5 2014
Externally publishedYes


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