Seroprevalence of Toxoplasma gondii antibodies in North Indian blood donors: Implications for transfusion transmissible toxoplasmosis

Priti Elhence, Prashant Agarwal, Kashi Nath Prasad, Rajendra K. Chaudhary

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Introduction: Transfusion transmitted Toxoplasma gondii (T. gondii) can result in significant clinical consequences in immunocompromised and multiply transfused patients, pregnant women and fetus etc. Anti-T. gondii seroprevalence, specifically IgM antibodies reflect the risk of transfusion transmission. Methods: Four hundred and ninety-three blood donors in a tertiary care hospital in North India were screened for IgG and IgM anti-T. gondii antibodies by enzyme linked immunosorbent assay (ELISA). Results: The prevalence of IgG and IgM anti-T. gondii antibodies was 51.8% and 5% respectively. The prevalence was higher in females (M = 51.6%, F = 89.2%) and in replacement donors (replacement donors = 63.2%, voluntary donors = 33.5%). Conclusion: The donor population constitutes a significant risk of transfusion transmitted toxoplasmosis. Effective strategies are required to prevent transfusion transmitted toxoplasmosis.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalTransfusion and Apheresis Science
Volume43
Issue number1
DOIs
StatePublished - Aug 2010
Externally publishedYes

Keywords

  • Blood donors
  • Seroprevalence
  • Toxoplasma gondii

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