TY - JOUR
T1 - Seroprevalence of Toxoplasma gondii antibodies in North Indian blood donors
T2 - Implications for transfusion transmissible toxoplasmosis
AU - Elhence, Priti
AU - Agarwal, Prashant
AU - Prasad, Kashi Nath
AU - Chaudhary, Rajendra K.
PY - 2010/8
Y1 - 2010/8
N2 - Introduction: Transfusion transmitted Toxoplasma gondii (T. gondii) can result in significant clinical consequences in immunocompromised and multiply transfused patients, pregnant women and fetus etc. Anti-T. gondii seroprevalence, specifically IgM antibodies reflect the risk of transfusion transmission. Methods: Four hundred and ninety-three blood donors in a tertiary care hospital in North India were screened for IgG and IgM anti-T. gondii antibodies by enzyme linked immunosorbent assay (ELISA). Results: The prevalence of IgG and IgM anti-T. gondii antibodies was 51.8% and 5% respectively. The prevalence was higher in females (M = 51.6%, F = 89.2%) and in replacement donors (replacement donors = 63.2%, voluntary donors = 33.5%). Conclusion: The donor population constitutes a significant risk of transfusion transmitted toxoplasmosis. Effective strategies are required to prevent transfusion transmitted toxoplasmosis.
AB - Introduction: Transfusion transmitted Toxoplasma gondii (T. gondii) can result in significant clinical consequences in immunocompromised and multiply transfused patients, pregnant women and fetus etc. Anti-T. gondii seroprevalence, specifically IgM antibodies reflect the risk of transfusion transmission. Methods: Four hundred and ninety-three blood donors in a tertiary care hospital in North India were screened for IgG and IgM anti-T. gondii antibodies by enzyme linked immunosorbent assay (ELISA). Results: The prevalence of IgG and IgM anti-T. gondii antibodies was 51.8% and 5% respectively. The prevalence was higher in females (M = 51.6%, F = 89.2%) and in replacement donors (replacement donors = 63.2%, voluntary donors = 33.5%). Conclusion: The donor population constitutes a significant risk of transfusion transmitted toxoplasmosis. Effective strategies are required to prevent transfusion transmitted toxoplasmosis.
KW - Blood donors
KW - Seroprevalence
KW - Toxoplasma gondii
UR - http://www.scopus.com/inward/record.url?scp=77955413196&partnerID=8YFLogxK
U2 - 10.1016/j.transci.2010.05.004
DO - 10.1016/j.transci.2010.05.004
M3 - Article
C2 - 20605111
AN - SCOPUS:77955413196
VL - 43
SP - 37
EP - 40
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
SN - 1473-0502
IS - 1
ER -