Serosurvey of Human Antibodies Recognizing Aedes aegypti D7 Salivary Proteins in Colombia

Berlin L. Londono-Renteria, Heman Shakeri, Paula Rozo-Lopez, Michael J. Conway, Natasha Duggan, Majid Jaberi-Douraki, Tonya M. Colpitts

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background: Dengue is one of the most geographically significant mosquito-borne viral diseases transmitted by Aedes mosquitoes. During blood feeding, mosquitoes deposit salivary proteins that induce antibody responses. These can be related to the intensity of exposure to bites. Some mosquito salivary proteins, such as D7 proteins, are known as potent allergens. The antibody response to D7 proteins can be used as a marker to evaluate the risk of exposure and disease transmission and provide critical information for understanding the dynamics of vector–host interactions. Methods: The study was conducted at the Los Patios Hospital, Cucuta, Norte de Santander, Colombia. A total of 63 participants were enrolled in the study. Participants were categorized into three disease status groups, age groups, and socioeconomic strata. The level of IgG antibodies against D7 Aedes proteins was determined by ELISA. We used a statistical approach to determine if there is an association between antibody levels and factors such as age, living conditions, and dengue virus (DENV) infection. Results: We found that IgG antibodies against D7 proteins were higher in non-DENV infected individuals in comparison to DENV-infected participants. Also, the age factor showed a significant positive correlation with IgG antibodies against D7 proteins, and the living conditions (socioeconomic stratification), in people aged 20 years or older, are a statistically significant factor in the variability of IgG antibodies against D7 proteins. Conclusion: This pilot study represents the first approximation to elucidate any correlation between the antibody response against mosquito D7 salivary proteins and its correlation with age, living conditions, and DENV infection in a dengue endemic area.

Original languageEnglish
Article number111
JournalFrontiers in Public Health
StatePublished - May 18 2018


  • Aedes saliva
  • D7
  • antibody levels
  • biomarker
  • dengue


Dive into the research topics of 'Serosurvey of Human Antibodies Recognizing Aedes aegypti D7 Salivary Proteins in Colombia'. Together they form a unique fingerprint.

Cite this