TY - JOUR
T1 - Severe hepatitis associated with oxacillin therapy
AU - Al-Homaidhi, Hossam
AU - Abdel-Haq, Nahed M.
AU - El-Baba, Mohammad
AU - Asmar, Basim I.
PY - 2002
Y1 - 2002
N2 - A 6-year-old girl had fever, abdominal pain, and severe anicteric hepatitis during intravenous oxacillin therapy for staphylococcal osteomyelitis. She had greatly elevated liver enzymes, prolonged prothrombin time, leukopenia, and eosinophilia. Clinical symptoms resolved and laboratory data returned to normal after withdrawing oxacillin and substituting cefazolin. This hepatotoxicity appears to be specific to oxacillin and not to other β-lactams. Monitoring liver function tests during oxacillin therapy, especially in patients receiving prolonged treatment, may be warranted.
AB - A 6-year-old girl had fever, abdominal pain, and severe anicteric hepatitis during intravenous oxacillin therapy for staphylococcal osteomyelitis. She had greatly elevated liver enzymes, prolonged prothrombin time, leukopenia, and eosinophilia. Clinical symptoms resolved and laboratory data returned to normal after withdrawing oxacillin and substituting cefazolin. This hepatotoxicity appears to be specific to oxacillin and not to other β-lactams. Monitoring liver function tests during oxacillin therapy, especially in patients receiving prolonged treatment, may be warranted.
UR - http://www.scopus.com/inward/record.url?scp=0036086656&partnerID=8YFLogxK
U2 - 10.1097/00007611-200295060-00015
DO - 10.1097/00007611-200295060-00015
M3 - Article
C2 - 12081223
AN - SCOPUS:0036086656
SN - 0038-4348
VL - 95
SP - 650
EP - 652
JO - Southern Medical Journal
JF - Southern Medical Journal
IS - 6
ER -