TY - JOUR
T1 - Sirolimus rescue for tacrolimus-associated post-transplant autoimmune hemolytic anemia
AU - Valentini, Rudolph P.
AU - Imam, Abubakr
AU - Warrier, Indira
AU - Ellis, Demetrius
AU - Ritchey, Akim
AU - Ravindranath, Yaddanapudi
AU - Shapiro, Ron
AU - Moritz, Michael L.
PY - 2006/5
Y1 - 2006/5
N2 - Autoimmune hemolytic anemia (AIHA) has been reported to occur after renal transplantation, and typically does so in the first few weeks post-transplant. We report on a 3-yr-old child who developed cold AIHA nearly 1 yr after an ABO identical, living donor renal transplant from his mother. Numerous transfusions, pulse steroids, repeat plasma exchange treatments, and IVIG were unsuccessful. Nearly 3 wk into his illness, tacrolimus was changed to cyclosporine, and then to sirolimus, and resulted in a prompt response. He currently has a normal renal function and a normal hemoglobin level on sirolimus monotherapy.
AB - Autoimmune hemolytic anemia (AIHA) has been reported to occur after renal transplantation, and typically does so in the first few weeks post-transplant. We report on a 3-yr-old child who developed cold AIHA nearly 1 yr after an ABO identical, living donor renal transplant from his mother. Numerous transfusions, pulse steroids, repeat plasma exchange treatments, and IVIG were unsuccessful. Nearly 3 wk into his illness, tacrolimus was changed to cyclosporine, and then to sirolimus, and resulted in a prompt response. He currently has a normal renal function and a normal hemoglobin level on sirolimus monotherapy.
KW - Autoimmune hemolytic anemia
KW - Kidney transplantation
KW - Pediatrics
KW - Refractory
KW - Sirolimus
KW - Tacrolimus
UR - http://www.scopus.com/inward/record.url?scp=33646235411&partnerID=8YFLogxK
U2 - 10.1111/j.1399-3046.2005.00460.x
DO - 10.1111/j.1399-3046.2005.00460.x
M3 - Article
C2 - 16677361
AN - SCOPUS:33646235411
SN - 1397-3142
VL - 10
SP - 358
EP - 361
JO - Pediatric Transplantation
JF - Pediatric Transplantation
IS - 3
ER -