Sodium increases plasma lipid peroxidation and heart/body weight in female rats on a high lipid diet

R. D. McCabe, J. M. Matz

Research output: Contribution to journalArticlepeer-review

Abstract

We determined how dietary sodium alters plasma lipid peroxidation (thiobarbituric acid reactive substances [TEARS], as nmol of malondialdehyde [MDA] per L) and normalized heart weight. Female, 6 week old Sprague-Dawley rate were fed a low (0.2%, n=5) or high (2.0%, n=6) sodium diet. To reduce any rate-limiting effects of plasma lipids, diets contained 4% cholesterol and 10% coconut oil, with 2% cholic acid added to facilitate absorption. At 10 weeks of age total cholesterol was very high in low (922±212 mg/dL [mean±SE]) and high (1177±94 mg/dL) sodium groups, but not different (p=0.27 by unpaired t-test) between groups. Plasma TBARS was increased (p<0.01) in high (6.91±0.33 nmol MDA/L) versus low (4.88±0.49 nmol MDA/L) dietary sodium. Heart/body weight was also increased (p<0.01) in high (4.28±0.05 mg/g) versus low (3.77±0.16 mg/g) sodium groups. We conclude that increased dietary sodium increases plasma TBARS and normalized heart weight in female rats fed a high lipid diet. We suggest that free radical/lipid interactions may contribute to the pathophysiology of high sodium diets in females.

Original languageEnglish
Pages (from-to)A270
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997

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