Solid lipid curcumin particles protect medium spiny neuronal morphology, and reduce learning and memory deficits in the yac128 mouse model of huntington’s disease

Abeer Gharaibeh, Panchanan Maiti, Rebecca Culver, Shiela Heileman, Bhairavi Srinageshwar, Darren Story, Kristin Spelde, Leela Paladugu, Nikolas Munro, Nathan Muhn, Nivya Kolli, Julien Rossignol, Gary L. Dunbar

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Huntington’s disease (HD) is a genetic neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms, accompanied by massive neuronal degeneration in the striatum. In this study, we utilized solid lipid curcumin particles (SLCPs) and solid lipid particles (SLPs) to test their efficacy in reducing deficits in YAC128 HD mice. Eleven-month-old YAC128 male and female mice were treated orally with SLCPs (100 mg/kg) or equivalent volumes of SLPs or vehicle (phosphate-buffered saline) every other day for eight weeks. Learning and memory performance was assessed using an active-avoidance task on week eight. The mice were euthanized, and their brains were processed using Golgi-Cox staining to study the morphology of medium spiny neurons (MSNs) and Western blots to quantify amounts of DARPP-32, brain-derived neurotrophic factor (BDNF), TrkB, synaptophysin, and PSD-95. We found that both SLCPs and SLPs improved learning and memory in HD mice, as measured by the active avoidance task. We also found that SLCP and SLP treatments preserved MSNs arborization and spinal density and modulated synaptic proteins. Our study shows that SLCPs, as well as the lipid particles, can have therapeutic effects in old YAC128 HD mice in terms of recovering from HD brain pathology and cognitive deficits.

Original languageEnglish
Article number9542
Pages (from-to)1-15
Number of pages15
JournalInternational Journal of Molecular Sciences
Volume21
Issue number24
DOIs
StatePublished - Dec 2 2020

Keywords

  • Curcumin
  • Huntington’s disease
  • Lipids
  • MSNs
  • YAC128

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