Soluble factors from neuronal cultures induce a specific proliferation and resistance to apoptosis of cognate mouse skeletal muscle precursor cells

Maude Pelletier, Julien Rossignol, Lisa Oliver, Maryvonne Zampieri, Josiane Fontaine-Pérus, François M. Vallette, Laurent Lescaudron

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The mechanisms or the physiological events, which control the regeneration of skeletal muscle through muscle precursor cell multiplication and differentiation, are still largely unknown. To address the question of the involvement of neurons in this process, skeletal muscle progenitors were grown in the presence of conditioned media obtained from 3-day-old cultures of embryonic neurons (derived from either the dorsal or the ventral region of 11-day-old mouse embryos) or media conditioned with satellite cells. Strikingly, only satellite cells cultured in medium conditioned from ventral embryonic neurons exhibited increased proliferation, as well as resistance to staurosporine (STS)-induced apoptosis. Our results suggest the existence of specific anti-apoptogenic neural soluble signals, which could be involved in skeletal muscle regeneration pathways.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalNeuroscience Letters
Volume407
Issue number1
DOIs
StatePublished - Oct 16 2006

Keywords

  • Expansion
  • Muscle precursor cells
  • Neuron
  • Survival

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