Structures of EF-hand Ca2+-binding proteins: Diversity in the organization, packing and response to Ca2+ binding

Melanie R. Nelson, Walter J. Chazin

Research output: Contribution to journalArticlepeer-review

185 Scopus citations

Abstract

The growing database of three-dimensional structures of EF-hand calcium-binding proteins is revealing a previously unrecognized variability in the coformations and organizations of EF-hand binding motifs. The structures of twelve different EF-hand proteins for which coordinates are publicly available are discussed and related to their respective biological and biophysical properties. The classical picture of calcium sensors and calcium signal modulators is presented, along with variants on the basic theme and new structural paradigms.

Original languageEnglish
Pages (from-to)297-318
Number of pages22
JournalBioMetals
Volume11
Issue number4
DOIs
StatePublished - 1998

Keywords

  • Ca signaling
  • Ca-binding protein
  • Calmodulin
  • EF-hand
  • Protein structure
  • Signal transduction

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