TY - JOUR
T1 - Stunned and hibernating myocardium
AU - Kloner, R. A.
AU - Przyklenk, K.
PY - 1991
Y1 - 1991
N2 - Myocardium that is not functioning may be dead (infarct or scar), viable but stunned (postischemic ventricular dysfunction), viable but hibernating (chronic low flow state), or acutely ischemic. Stunned myocardium has clearly been documented (a) in experimental studies of brief coronary artery occlusion followed by reperfusion, and (b) in myocardial infarct models in which early reperfusion salvages viable tissue. Recent clinical studies have confirmed the existence of stunned myocardium in humans. Evidence supporting the concept of hibernating myocardium comes from clinical studies in which patients with chronic low flow ischemia exhibit improvement in left ventricular function (sometimes immediately) following revascularization.
AB - Myocardium that is not functioning may be dead (infarct or scar), viable but stunned (postischemic ventricular dysfunction), viable but hibernating (chronic low flow state), or acutely ischemic. Stunned myocardium has clearly been documented (a) in experimental studies of brief coronary artery occlusion followed by reperfusion, and (b) in myocardial infarct models in which early reperfusion salvages viable tissue. Recent clinical studies have confirmed the existence of stunned myocardium in humans. Evidence supporting the concept of hibernating myocardium comes from clinical studies in which patients with chronic low flow ischemia exhibit improvement in left ventricular function (sometimes immediately) following revascularization.
KW - Angioplasty
KW - Myocardial infarction
KW - Myocardial ischemia
KW - Myocardial reperfusion
KW - Thrombolysis
UR - http://www.scopus.com/inward/record.url?scp=0025821594&partnerID=8YFLogxK
U2 - 10.1146/annurev.me.42.020191.000245
DO - 10.1146/annurev.me.42.020191.000245
M3 - Review article
C2 - 2035955
AN - SCOPUS:0025821594
VL - 42
SP - 1
EP - 8
JO - Annual Review of Medicine
JF - Annual Review of Medicine
SN - 0066-4219
ER -