Syncytial variant nodular sclerosis classical Hodgkin Lymphoma in an adolescent and review of the literature: A unique entity

Eman Al-Antary, Rohith Jesudas, Amy George, Janet Poulik, Süreyya Savaşan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Syncytial variant of nodular sclerosis (SV-NS) classical Hodgkin lymphoma (cHL) with its histologic features and clinical presentation is uncommon in adults and extremely rare in children. Here, we report a female teenager presenting with long-standing B symptoms, prominent soft tissue and bone involvement mimicking sarcoma and significant nodal disease who is diagnosed with advanced SV-NS cHL. Rare Reed-Sternberg-like cells displaying neutrophil and erythrocyte emperipolesis were seen on bone marrow aspiration slides. Despite initial complete response to chemotherapy and radiotherapy, the patient experienced early relapse suggestive of high-risk biology. This variant may constitute a unique entity.

Original languageEnglish
Pages (from-to)E167-E170
JournalJournal of Pediatric Hematology/Oncology
Volume41
Issue number3
DOIs
StatePublished - Apr 1 2019

Keywords

  • Chest wall bone involvement
  • Hodgkin lymphoma
  • Neutrophil emperipolesis by Reed-Sternberg-like cells
  • Syncytial variant nodular sclerosis subtype

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