Synthesis and CD structural studies of CD52 peptides and glycopeptides

Benjamin M. Swarts, Yu Cheng Chang, Honggang Hu, Zhongwu Guo

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The syntheses of five natural and N-terminal acetylated peptides and glycopeptides of the CD52 antigen are described. Solid phase peptide synthesis was employed in the construction of the target compounds from Fmoc-protected commercial amino acids and synthetic glycan-asparagine conjugates. Circular dichroism studies of the synthetic targets showed that they exist as random coils in solution, and no significant change in secondary structure was observed when the CD52 peptide was either acetylated at the N-terminus or glycosylated at the Asn3 residue with a disaccharide or a fucose-containing branched trisaccharide.

Original languageEnglish
Pages (from-to)2894-2902
Number of pages9
JournalCarbohydrate Research
Issue number17
StatePublished - Nov 24 2008


  • CD52
  • Circular dichroism (CD)
  • Glycopeptide
  • N-Glycosylation
  • Peptide
  • Solid phase synthesis


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