TY - JOUR
T1 - Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system
T2 - Cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells
AU - Zhang, Haiyuan
AU - Thomas, Ronald
AU - Oupicky, David
AU - Peng, Fangyu
N1 - Funding Information:
Acknowledgements We thank Claudio Verani for help in chemical characterization of the complexes and Jiu-sheng Wu for technical assistance. This project was partly funded by a faculty research development award from the Carman and Ann Adams Foundation and a new investigator award from Fighting Children’s Cancer Foundation to Fangyu Peng.
PY - 2008/1
Y1 - 2008/1
N2 - Two new copper thiosemicarbazone complexes with an ONNS quadridentate system were synthesized and evaluated for anticancer activity on cisplatin-resistant neuroblastoma cells. Among these two copper complexes, the substituted 8-hydroxyquinoline-2-carboxaldehyde-4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) exhibited stronger cell growth inhibition activity than the unsubstituted copper 8-hydroxyquinoline-2-carboxaldehyde thiosemicarbazide complex (CuHQTS). Both CuHQTS and CuHQDMTS showed dose-dependent cell growth inhibition, cell cycle arrest and apoptosis induction activities on the SK-N-DZ neuroblastoma cells. Increased expression of p53 protein molecules was detected in the SK-N-DZ cells treated with CuHQTS. The data obtained in this study suggest that CuHQDMTS and CuHQTS hold potential as new, effective drugs for treatment of refractory neuroblastoma in children.
AB - Two new copper thiosemicarbazone complexes with an ONNS quadridentate system were synthesized and evaluated for anticancer activity on cisplatin-resistant neuroblastoma cells. Among these two copper complexes, the substituted 8-hydroxyquinoline-2-carboxaldehyde-4,4-dimethyl-3-thiosemicarbazide (CuHQDMTS) exhibited stronger cell growth inhibition activity than the unsubstituted copper 8-hydroxyquinoline-2-carboxaldehyde thiosemicarbazide complex (CuHQTS). Both CuHQTS and CuHQDMTS showed dose-dependent cell growth inhibition, cell cycle arrest and apoptosis induction activities on the SK-N-DZ neuroblastoma cells. Increased expression of p53 protein molecules was detected in the SK-N-DZ cells treated with CuHQTS. The data obtained in this study suggest that CuHQDMTS and CuHQTS hold potential as new, effective drugs for treatment of refractory neuroblastoma in children.
KW - Apoptosis
KW - Cell cycle arrest
KW - Copper
KW - Proliferation inhibition
KW - Thiosemicarbazone
UR - http://www.scopus.com/inward/record.url?scp=36649030309&partnerID=8YFLogxK
U2 - 10.1007/s00775-007-0299-6
DO - 10.1007/s00775-007-0299-6
M3 - Article
C2 - 17909866
AN - SCOPUS:36649030309
SN - 0949-8257
VL - 13
SP - 47
EP - 55
JO - Journal of Biological Inorganic Chemistry
JF - Journal of Biological Inorganic Chemistry
IS - 1
ER -