Synthesis and characterization of water-soluble and photostable L-Dopa dendrimers.

S Tang; Ajit Sharma; Minghui Chai

Synthesis and characterization of water-soluble and photostable L-Dopa dendrimers.

S Tang, Ajit Sharma, Minghui Chai

https://www.cmich.edu/academics/colleges/college-science-engineering/departments-schools/chemistry-and-biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A small drug molecule, L-DOPA, was converted into well-defined dendritic macromolecules. Their monodisperse nature was shown by NMR, MALDI-TOF-MS, and PAGE. A third-generation L-Dopa dendrimer contained 30 L-Dopa residues, which made up its core, branches, and periphery. Individual L-Dopa moieties in the dendrimer were connected to one another via hydrolyzable diester linkages. These Dopa dendrimers showed a 20-fold increase in aqueous solubility and enhanced photostability in solutions over L-Dopa under identical conditions.

Original language	English
Pages (from-to)	4421-4424
Journal	Organic Letters
Volume	8
State	Published - 2006

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title = "Synthesis and characterization of water-soluble and photostable L-Dopa dendrimers.",

abstract = "A small drug molecule, L-DOPA, was converted into well-defined dendritic macromolecules. Their monodisperse nature was shown by NMR, MALDI-TOF-MS, and PAGE. A third-generation L-Dopa dendrimer contained 30 L-Dopa residues, which made up its core, branches, and periphery. Individual L-Dopa moieties in the dendrimer were connected to one another via hydrolyzable diester linkages. These Dopa dendrimers showed a 20-fold increase in aqueous solubility and enhanced photostability in solutions over L-Dopa under identical conditions.",

author = "S Tang and Ajit Sharma and Minghui Chai",

year = "2006",

language = "English",

volume = "8",

pages = "4421--4424",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "Organic Letters",

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TY - JOUR

T1 - Synthesis and characterization of water-soluble and photostable L-Dopa dendrimers.

AU - Tang, S

AU - Sharma, Ajit

AU - Chai, Minghui

PY - 2006

Y1 - 2006

N2 - A small drug molecule, L-DOPA, was converted into well-defined dendritic macromolecules. Their monodisperse nature was shown by NMR, MALDI-TOF-MS, and PAGE. A third-generation L-Dopa dendrimer contained 30 L-Dopa residues, which made up its core, branches, and periphery. Individual L-Dopa moieties in the dendrimer were connected to one another via hydrolyzable diester linkages. These Dopa dendrimers showed a 20-fold increase in aqueous solubility and enhanced photostability in solutions over L-Dopa under identical conditions.

AB - A small drug molecule, L-DOPA, was converted into well-defined dendritic macromolecules. Their monodisperse nature was shown by NMR, MALDI-TOF-MS, and PAGE. A third-generation L-Dopa dendrimer contained 30 L-Dopa residues, which made up its core, branches, and periphery. Individual L-Dopa moieties in the dendrimer were connected to one another via hydrolyzable diester linkages. These Dopa dendrimers showed a 20-fold increase in aqueous solubility and enhanced photostability in solutions over L-Dopa under identical conditions.

M3 - Article

SN - 1523-7060

VL - 8

SP - 4421

EP - 4424

JO - Organic Letters

JF - Organic Letters

ER -

Synthesis and characterization of water-soluble and photostable L-Dopa dendrimers.

Abstract

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