Synthesis, characterization, and aqueous self-assembly of amphiphilic poly(ethylene oxide)-functionalized hyperbranched fluoropolymers

Wenjun Du, Yali Li, Andreas M. Nyström, Chong Cheng, Karen L. Wooley

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Complex amphiphilic polymers were synthesized via core-first polymerization followed by alkylation-based grafting of poly(ethylene oxide) (PEO). Inimer 1-(4′-(bromomethyl)benzyloxy)-2,3,5,6-tetrafluoro-4-vinylbenzene was synthesized and subjected to atom transfer radical self-condensing vinyl polymerization to afford hyperbranched fluoropolymer (HBFP) as the hydrophobic core component with a number-averaged molecular weight of 29 kDa and polydispersity index of 2.1. The alkyl halide chain ends on the HBFP were allowed to undergo reaction with monomethoxy-terminated polyethylene oxide) amine (PEOx-NH2) at different grafting numbers and PEO chain lengths to afford PEO-functionalized HBFPs [(PEOx) yHBFPs], with x = 15 while y = 16, 22, or 29, x = 44 while y = 16, and x = 112 while y = 16. The amphiphilic, grafted block copolymers were found to aggregate in aqueous solution to give micelles with number-averaged diameters (Dav) of 12-28 nm, as measured by transmission electron microscopy (TEM). An increase of the PEO:HBFP ratio, by increase in either the grafting densities (y values) or the chain lengths (x values), led to decreased TEM-measured diameters. These complex, amphiphilic (PEOx) y-HBFPs, with tunable sizes, might find potential applications as nanoscopic biomedical devices, such as drug delivery vehicles and 19F magnetic resonance imaging agents.

Original languageEnglish
Pages (from-to)3487-3496
Number of pages10
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume48
Issue number15
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

Keywords

  • Amphiphiles
  • Fluoropolymers
  • Hyperbranched
  • Micelles
  • Self-assembly

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