Synthesis of a glycosylphosphatidylinositol anchor bearing unsaturated lipid chains

Benjamin M. Swarts; Zhongwu Guo

doi:10.1021/ja1009037

Synthesis of a glycosylphosphatidylinositol anchor bearing unsaturated lipid chains

Benjamin M. Swarts, Zhongwu Guo

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51 Scopus citations

Abstract

A GPI anchor bearing unsaturated fatty acid lipid chains (1) was synthesized by a highly convergent strategy employing the para-methoxybenzyl group for permanent hydroxyl protection. The final global deprotection was achieved by an efficient three-step, one-pot procedure to give an 81% isolated yield of the target structure.

Original language	English
Pages (from-to)	6648-6650
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	132
Issue number	19
DOIs	https://doi.org/10.1021/ja1009037
State	Published - May 19 2010

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title = "Synthesis of a glycosylphosphatidylinositol anchor bearing unsaturated lipid chains",

abstract = "A GPI anchor bearing unsaturated fatty acid lipid chains (1) was synthesized by a highly convergent strategy employing the para-methoxybenzyl group for permanent hydroxyl protection. The final global deprotection was achieved by an efficient three-step, one-pot procedure to give an 81% isolated yield of the target structure.",

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AU - Guo, Zhongwu

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AB - A GPI anchor bearing unsaturated fatty acid lipid chains (1) was synthesized by a highly convergent strategy employing the para-methoxybenzyl group for permanent hydroxyl protection. The final global deprotection was achieved by an efficient three-step, one-pot procedure to give an 81% isolated yield of the target structure.

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

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Synthesis of a glycosylphosphatidylinositol anchor bearing unsaturated lipid chains

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