Synthesis of a glycosylphosphatidylinositol anchor bearing unsaturated lipid chains

Benjamin M. Swarts, Zhongwu Guo

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

A GPI anchor bearing unsaturated fatty acid lipid chains (1) was synthesized by a highly convergent strategy employing the para-methoxybenzyl group for permanent hydroxyl protection. The final global deprotection was achieved by an efficient three-step, one-pot procedure to give an 81% isolated yield of the target structure.

Original languageEnglish
Pages (from-to)6648-6650
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number19
DOIs
StatePublished - May 19 2010

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