Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies

Liye Fu; Lingyao Li; Jun Wang; Kyle Knickelbein; Lin Zhang; Ian Milligan; Yi Xu; Kylie O’hara; Lindsay Bitterman; Wenjun Du

doi:10.1039/c4cc06343k

Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies

Liye Fu, Lingyao Li, Jun Wang, Kyle Knickelbein, Lin Zhang, Ian Milligan, Yi Xu, Kylie O’hara, Lindsay Bitterman, Wenjun Du

Chemistry & Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of clickable polysaccharides was achieved by using alkynylated 1,6-anhydro glucopyranose as a monomer and BF₃·OEt₂ as an effective catalyst. Subsequent click conjugation with polyethylene glycol (PEG) afforded PEG-grafted polysaccharides in nearly quantitative efficiency.

Original language	English
Pages (from-to)	12742-12745
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	84
DOIs	https://doi.org/10.1039/c4cc06343k
State	Published - Sep 25 2014

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title = "Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies",

abstract = "The synthesis of clickable polysaccharides was achieved by using alkynylated 1,6-anhydro glucopyranose as a monomer and BF3·OEt2 as an effective catalyst. Subsequent click conjugation with polyethylene glycol (PEG) afforded PEG-grafted polysaccharides in nearly quantitative efficiency.",

author = "Liye Fu and Lingyao Li and Jun Wang and Kyle Knickelbein and Lin Zhang and Ian Milligan and Yi Xu and Kylie O{\textquoteright}hara and Lindsay Bitterman and Wenjun Du",

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AU - Fu, Liye

AU - Li, Lingyao

AU - Wang, Jun

AU - Knickelbein, Kyle

AU - Zhang, Lin

AU - Milligan, Ian

AU - Xu, Yi

AU - O’hara, Kylie

AU - Bitterman, Lindsay

AU - Du, Wenjun

PY - 2014/9/25

Y1 - 2014/9/25

N2 - The synthesis of clickable polysaccharides was achieved by using alkynylated 1,6-anhydro glucopyranose as a monomer and BF3·OEt2 as an effective catalyst. Subsequent click conjugation with polyethylene glycol (PEG) afforded PEG-grafted polysaccharides in nearly quantitative efficiency.

AB - The synthesis of clickable polysaccharides was achieved by using alkynylated 1,6-anhydro glucopyranose as a monomer and BF3·OEt2 as an effective catalyst. Subsequent click conjugation with polyethylene glycol (PEG) afforded PEG-grafted polysaccharides in nearly quantitative efficiency.

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DO - 10.1039/c4cc06343k

M3 - Article

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VL - 50

SP - 12742

EP - 12745

JO - Chemical Communications

JF - Chemical Communications

IS - 84

ER -

Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies

Abstract

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