Synthesis of non-steroidal antiinflammatory drug analogues for selective studies on the COX-II enzyme

Steven A. Fleming, Michael D. Ridges, Anton W. Jensen

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Synthesis of the azido substituted non-steroidal inflammatory drug 2-(2,6-dichloroanilino)phenylacetic acid and isotope labeling of this compound have been performed and are described. Initial evaluation of the binding ability and photoreactivity indicates that this compound has potential for photoaffinity labeling as well as enzyme selectivity studies.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume38
Issue number1
DOIs
StatePublished - 1996

Keywords

  • COX-II
  • azido diclofenac
  • photoaffinity labeling

Fingerprint

Dive into the research topics of 'Synthesis of non-steroidal antiinflammatory drug analogues for selective studies on the COX-II enzyme'. Together they form a unique fingerprint.

Cite this