T Cell Deficiency

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


T cell deficiency, also called as cell-mediated immune deficiency, accounts for 5-10% of all primary immune deficiency diseases. This form of immune deficiency is characterized by reduced number of peripheral blood T cell and/or reduced proliferative response to mitogens. Patients are predisposed to recurrent, severe infections, failure to thrive, and chronic diarrhea. Inclusion of T cell receptor circles (TREC) in newborn screen at birth has facilitated early identification of T cell lymphopenia. Early diagnosis and treatment via immune reconstitution are essential for survival in such patients. Patients with life-threatening T cell deficiency are often maintained on antimicrobial prophylaxis to prevent opportunistic infections. Severe combined immune deficiency (SCID) and DiGeorge Syndrome (DGS) are prototype of primary T cell immunodeficiency diseases and will be our primary discussion in this chapter. We will start with cases of T cell immunodeficiency disorders and discuss the diseases in detail including clinical presentation, diagnosis, and management.

Original languageEnglish
Title of host publicationAbsolute Allergy and Immunology Board Review
PublisherSpringer International Publishing
Number of pages12
ISBN (Electronic)9783031128677
ISBN (Print)9783031128660
StatePublished - Jan 1 2022
Externally publishedYes


  • DiGeorge syndrome (DGS)
  • Infection
  • Mitogen
  • Newborn screen
  • Severe combined immune deficiency (SCID)
  • T cell
  • TREC
  • Thymus


Dive into the research topics of 'T Cell Deficiency'. Together they form a unique fingerprint.

Cite this