Targeting coagulation mediators in head and neck cancer

Rohith Jesudas, Qinghua Zeng, Danielle M. Garshott, Nicholas Yoo, Andrew M. Fribley, Jordan A. Shavit, Michael U. Callaghan

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


This chapter examines the role of the coagulation system in cancer. While the role of a prothrombotic state was linked to cancer development many years ago, effective targeting of mediators of coagulation is not yet an element of cancer therapy. In the last decade, multiple novel anticoagulants have been approved for use in the prevention or treatment of thrombotic conditions. The presence of a larger armamentarium of medications with fewer bleeding side effects makes them suitable adjuncts in the multimodal treatment of cancer.

Original languageEnglish
Title of host publicationTargeting Oral Cancer
PublisherSpringer International Publishing
Number of pages19
ISBN (Electronic)9783319276472
ISBN (Print)9783319276458
StatePublished - Jan 1 2016


  • Coagulation
  • Fibrinogen
  • Head and neck cancer
  • Hemostasis
  • Metastasis
  • OSCC
  • Oral cancer
  • Thrombin
  • Thrombosis
  • Von Willebrand factor


Dive into the research topics of 'Targeting coagulation mediators in head and neck cancer'. Together they form a unique fingerprint.

Cite this