The developmental timing regulator hbl-1 modulates the dauer formation decision in Caenorhabditis elegans

Xantha Karp, Victor Ambros

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Animals developing in the wild encounter a range of environmental conditions, and so developmental mechanisms have evolved that can accommodate different environmental contingencies. Harsh environmental conditions cause Caenorhabditis elegans larvae to arrest as stress-resistant "dauer" larvae after the second larval stage (L2), thereby indefinitely postponing L3 cell fates. HBL-1 is a key transcriptional regulator of L2 vs. L3 cell fate. Through the analysis of genetic interactions between mutations of hbl-1 and of genes encoding regulators of dauer larva formation, we find that hbl-1 can also modulate the dauer formation decision in a complex manner. We propose that dynamic interactions between genes that regulate stage-specific cell fate decisions and those that regulate dauer formation promote the robustness of developmental outcomes to changing environmental conditions.

Original languageEnglish
Pages (from-to)345-353
Number of pages9
JournalGenetics
Volume187
Issue number1
DOIs
StatePublished - Jan 2011

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