The Effect of Acute Glutamine Supplementation on Markers of Inflammation and Fatigue During Consecutive Days of Simulated Wildland Firefighting

Roberto C. Nava; Micah N. Zuhl; Terence A. Moriarty; Fabiano T. Amorim; Kelsey C. Bourbeau; Anna M. Welch; James J. Mccormick; Kelli E. King; Christine M. Mermier

doi:10.1097/JOM.0000000000001507

The Effect of Acute Glutamine Supplementation on Markers of Inflammation and Fatigue During Consecutive Days of Simulated Wildland Firefighting

Roberto C. Nava, Micah N. Zuhl, Terence A. Moriarty, Fabiano T. Amorim, Kelsey C. Bourbeau, Anna M. Welch, James J. Mccormick, Kelli E. King, Christine M. Mermier

Health Sciences, School Of

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10 Scopus citations

Abstract

Objective:To examine the effect of oral glutamine supplementation on inflammation and fatigue during and after simulated wildland firefighting (WLFF) tasks in hot conditions over 2 consecutive days.Methods:Eleven men and women ingested a glutamine supplement or a placebo before and after simulated wildland firefighting in an environmental chamber (38°C, 35% relative humidity). Subjective fatigue, markers of inflammation, and cellular stress were measured pre, post and 4hours post-exercise on both days.Results:Gastrointestinal damage, subjective fatigue, and ratings of perceived exertion were lower after glutamine supplementation compared with placebo. Heat shock protein 70 (HSP70) and nuclear factor kappa-inhibitor alpha (IκBα) levels were higher on both days of the glutamine trial compared with placebo.Conclusions:Glutamine supplementation may improve recovery after fire suppression in WLFFs. This may result from the upregulation of HSP70 which inhibits inflammation and protects against gastrointestinal (GI) barrier damage.

Original language	English
Pages (from-to)	E33-E42
Journal	Journal of Occupational and Environmental Medicine
Volume	61
Issue number	2
DOIs	https://doi.org/10.1097/JOM.0000000000001507
State	Published - Feb 1 2019

Keywords

gastrointestinal permeability
heat shock protein 70
heat stress
inhibitor
intestinal fatty acid binding protein
nuclear factor kappa-inhibitor alpha

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/JOM.0000000000001507

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Nava, R. C., Zuhl, M. N., Moriarty, T. A., Amorim, F. T., Bourbeau, K. C., Welch, A. M., Mccormick, J. J., King, K. E., & Mermier, C. M. (2019). The Effect of Acute Glutamine Supplementation on Markers of Inflammation and Fatigue During Consecutive Days of Simulated Wildland Firefighting. Journal of Occupational and Environmental Medicine, 61(2), E33-E42. https://doi.org/10.1097/JOM.0000000000001507

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title = "The Effect of Acute Glutamine Supplementation on Markers of Inflammation and Fatigue During Consecutive Days of Simulated Wildland Firefighting",

abstract = "Objective:To examine the effect of oral glutamine supplementation on inflammation and fatigue during and after simulated wildland firefighting (WLFF) tasks in hot conditions over 2 consecutive days.Methods:Eleven men and women ingested a glutamine supplement or a placebo before and after simulated wildland firefighting in an environmental chamber (38°C, 35% relative humidity). Subjective fatigue, markers of inflammation, and cellular stress were measured pre, post and 4hours post-exercise on both days.Results:Gastrointestinal damage, subjective fatigue, and ratings of perceived exertion were lower after glutamine supplementation compared with placebo. Heat shock protein 70 (HSP70) and nuclear factor kappa-inhibitor alpha (IκBα) levels were higher on both days of the glutamine trial compared with placebo.Conclusions:Glutamine supplementation may improve recovery after fire suppression in WLFFs. This may result from the upregulation of HSP70 which inhibits inflammation and protects against gastrointestinal (GI) barrier damage.",

keywords = "gastrointestinal permeability, heat shock protein 70, heat stress, inhibitor, intestinal fatty acid binding protein, nuclear factor kappa-inhibitor alpha",

author = "Nava, {Roberto C.} and Zuhl, {Micah N.} and Moriarty, {Terence A.} and Amorim, {Fabiano T.} and Bourbeau, {Kelsey C.} and Welch, {Anna M.} and Mccormick, {James J.} and King, {Kelli E.} and Mermier, {Christine M.}",

note = "Funding Information: Sources of funding: University of New Mexico Overhead Funds Allocation Committee (OFAC) grant and University of New Mexico Research Alloca-tion Committee grant. Publisher Copyright: {\textcopyright} 2019 American College of Occupational and Environmental Medicine.",

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Nava, RC, Zuhl, MN, Moriarty, TA, Amorim, FT, Bourbeau, KC, Welch, AM, Mccormick, JJ, King, KE & Mermier, CM 2019, 'The Effect of Acute Glutamine Supplementation on Markers of Inflammation and Fatigue During Consecutive Days of Simulated Wildland Firefighting', Journal of Occupational and Environmental Medicine, vol. 61, no. 2, pp. E33-E42. https://doi.org/10.1097/JOM.0000000000001507

The Effect of Acute Glutamine Supplementation on Markers of Inflammation and Fatigue During Consecutive Days of Simulated Wildland Firefighting. / Nava, Roberto C.; Zuhl, Micah N.; Moriarty, Terence A. et al.
In: Journal of Occupational and Environmental Medicine, Vol. 61, No. 2, 01.02.2019, p. E33-E42.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The Effect of Acute Glutamine Supplementation on Markers of Inflammation and Fatigue During Consecutive Days of Simulated Wildland Firefighting

AU - Nava, Roberto C.

AU - Zuhl, Micah N.

AU - Moriarty, Terence A.

AU - Amorim, Fabiano T.

AU - Bourbeau, Kelsey C.

AU - Welch, Anna M.

AU - Mccormick, James J.

AU - King, Kelli E.

AU - Mermier, Christine M.

N1 - Funding Information: Sources of funding: University of New Mexico Overhead Funds Allocation Committee (OFAC) grant and University of New Mexico Research Alloca-tion Committee grant. Publisher Copyright: © 2019 American College of Occupational and Environmental Medicine.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Objective:To examine the effect of oral glutamine supplementation on inflammation and fatigue during and after simulated wildland firefighting (WLFF) tasks in hot conditions over 2 consecutive days.Methods:Eleven men and women ingested a glutamine supplement or a placebo before and after simulated wildland firefighting in an environmental chamber (38°C, 35% relative humidity). Subjective fatigue, markers of inflammation, and cellular stress were measured pre, post and 4hours post-exercise on both days.Results:Gastrointestinal damage, subjective fatigue, and ratings of perceived exertion were lower after glutamine supplementation compared with placebo. Heat shock protein 70 (HSP70) and nuclear factor kappa-inhibitor alpha (IκBα) levels were higher on both days of the glutamine trial compared with placebo.Conclusions:Glutamine supplementation may improve recovery after fire suppression in WLFFs. This may result from the upregulation of HSP70 which inhibits inflammation and protects against gastrointestinal (GI) barrier damage.

AB - Objective:To examine the effect of oral glutamine supplementation on inflammation and fatigue during and after simulated wildland firefighting (WLFF) tasks in hot conditions over 2 consecutive days.Methods:Eleven men and women ingested a glutamine supplement or a placebo before and after simulated wildland firefighting in an environmental chamber (38°C, 35% relative humidity). Subjective fatigue, markers of inflammation, and cellular stress were measured pre, post and 4hours post-exercise on both days.Results:Gastrointestinal damage, subjective fatigue, and ratings of perceived exertion were lower after glutamine supplementation compared with placebo. Heat shock protein 70 (HSP70) and nuclear factor kappa-inhibitor alpha (IκBα) levels were higher on both days of the glutamine trial compared with placebo.Conclusions:Glutamine supplementation may improve recovery after fire suppression in WLFFs. This may result from the upregulation of HSP70 which inhibits inflammation and protects against gastrointestinal (GI) barrier damage.

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KW - inhibitor

KW - intestinal fatty acid binding protein

KW - nuclear factor kappa-inhibitor alpha

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DO - 10.1097/JOM.0000000000001507

M3 - Article

C2 - 30489352

AN - SCOPUS:85061149423

SN - 1076-2752

VL - 61

SP - E33-E42

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

IS - 2

ER -

The Effect of Acute Glutamine Supplementation on Markers of Inflammation and Fatigue During Consecutive Days of Simulated Wildland Firefighting

Abstract

Keywords

UN SDGs

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