Objective:To examine the effect of oral glutamine supplementation on inflammation and fatigue during and after simulated wildland firefighting (WLFF) tasks in hot conditions over 2 consecutive days.Methods:Eleven men and women ingested a glutamine supplement or a placebo before and after simulated wildland firefighting in an environmental chamber (38°C, 35% relative humidity). Subjective fatigue, markers of inflammation, and cellular stress were measured pre, post and 4hours post-exercise on both days.Results:Gastrointestinal damage, subjective fatigue, and ratings of perceived exertion were lower after glutamine supplementation compared with placebo. Heat shock protein 70 (HSP70) and nuclear factor kappa-inhibitor alpha (IκBα) levels were higher on both days of the glutamine trial compared with placebo.Conclusions:Glutamine supplementation may improve recovery after fire suppression in WLFFs. This may result from the upregulation of HSP70 which inhibits inflammation and protects against gastrointestinal (GI) barrier damage.
|Journal||Journal of Occupational and Environmental Medicine|
|State||Published - Feb 1 2019|
- gastrointestinal permeability
- heat shock protein 70
- heat stress
- intestinal fatty acid binding protein
- nuclear factor kappa-inhibitor alpha