The Effects of Intermittent Fasting on Glycemic Control and Body Composition in Adults with Obesity and Type 2 Diabetes: A Systematic Review

Rosemarie Vitale, Yeonsoo Kim

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

The purpose of this study was to evaluate the effects of intermittent fasting on glycemic control and body composition in adults with obesity and type 2 diabetes. Although intermittent fasting has shown some promise in improving glucoregulatory indicators and body composition in adults with obesity, there is currently no systematic review evaluating these effects in adults with obesity and type 2 diabetes. A database search of PubMed, CINHAL, and MEDLINE identified five studies that met inclusion criterion. All studies were randomized controlled trials in adult subjects (n = 46-137) with type 2 diabetes and a body mass index of ≥30 kg/m2. Four different intermittent fasting regimens were reviewed. All fasting regimens revealed strong evidence to support intermittent fasting as a feasible diet to improve glycemia and body composition measures within 12-24 weeks. Follow-up 12-18 months after intermittent fasting did not show promising results for continued weight loss and improved glycemic control. The majority of the studies demonstrated insignificant differences between intermittent fasting and continuous energy restriction for measures of glycated hemoglobin a1c and body composition. More data on intermittent fasting in adults with obesity and type 2 diabetes are needed to determine its benefits within this patient population. Future research should include consistent fasting regimens and larger sample sizes to improve the reliability and generalizability of the data. Also, consistent follow-up after a fasting intervention may enhance long-term benefits and should be considered in future research.

Original languageEnglish
Pages (from-to)450-461
Number of pages12
JournalMetabolic Syndrome and Related Disorders
Volume18
Issue number10
DOIs
StatePublished - Dec 2020

Keywords

  • adults
  • glycated hemoglobin a1c
  • intermittent fasting
  • obesity
  • type 2 diabetes

Fingerprint

Dive into the research topics of 'The Effects of Intermittent Fasting on Glycemic Control and Body Composition in Adults with Obesity and Type 2 Diabetes: A Systematic Review'. Together they form a unique fingerprint.

Cite this