The frailty syndrome: A comprehensive review

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108 Scopus citations


The frailty syndrome is defined as unintentional weight and muscle loss, exhaustion, and declines in grip strength, gait speed, and activity. Evidence with respect to the clinical definition, epidemiology, mechanisms, interactions, assessment, prevention, and treatment of frailty in the older adult is reviewed.

Original languageEnglish
Pages (from-to)315-368
Number of pages54
JournalJournal of Nutrition in Gerontology and Geriatrics
Issue number4
StatePublished - Oct 2011


  • frailty
  • nutrition
  • older adult


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